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For Laboratory Research Use Only — Not For Human Consumption — Not A Drug, Food, Or CosmeticFor Laboratory Research Use Only — Not For Human Consumption — Not A Drug, Food, Or CosmeticFor Laboratory Research Use Only — Not For Human Consumption — Not A Drug, Food, Or CosmeticFor Laboratory Research Use Only — Not For Human Consumption — Not A Drug, Food, Or CosmeticFor Laboratory Research Use Only — Not For Human Consumption — Not A Drug, Food, Or CosmeticFor Laboratory Research Use Only — Not For Human Consumption — Not A Drug, Food, Or CosmeticFor Laboratory Research Use Only — Not For Human Consumption — Not A Drug, Food, Or CosmeticFor Laboratory Research Use Only — Not For Human Consumption — Not A Drug, Food, Or CosmeticFor Laboratory Research Use Only — Not For Human Consumption — Not A Drug, Food, Or CosmeticFor Laboratory Research Use Only — Not For Human Consumption — Not A Drug, Food, Or CosmeticFor Laboratory Research Use Only — Not For Human Consumption — Not A Drug, Food, Or CosmeticFor Laboratory Research Use Only — Not For Human Consumption — Not A Drug, Food, Or Cosmetic
LC RESEARCH CO.Premium Research Peptides
GLP-3 research vial
LC RESEARCH
GLP-3
10MG
99% PURITY
FOR RESEARCH PURPOSES ONLY
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GLP-3

LC-RETA-10 · 10mg vial

Triple agonist (GLP-3) of the glucagon, GIP, and GLP-1 receptors under investigation for metabolic and adiposity research.

Purity

99%

Availability

In Stock

$70.00

1

Molecular Formula
C221H342N46O68
Molecular Weight
4731.33 g/mol
Sequence
YXQGTFTSDYSILLDKKAQXAFIEYLLEGGPSSGAPPPS
Half-Life
~120 hrs
Physical Form
Lyophilized powder
Storage
-20°C, protect from light
Purity (HPLC)
99%
SKU
LC-RETA-10

Research Dossier

GLP-3 — Preclinical Profile

A plain-language mechanism of action and a general laboratory research protocol — compiled from published research literature.

LC-RETA-10

For laboratory research only. The information below summarizes published research literature and is provided for reference by qualified laboratory personnel. It is not medical advice and makes no therapeutic claims. These products are not for human or veterinary use, diagnosis, or treatment, and have not been evaluated by the FDA.

Mechanism of Action

Retatrutide is a triple agonist that simultaneously activates three specific receptors in the body: GLP-1, GIP, and glucagon. By binding to these receptors, it helps regulate how the body processes sugar and manages energy. This combined action is studied for its potential to influence appetite, insulin release, and metabolic balance.

Primary Research Areas

Incretin and glucagon receptor signaling and cross-talkReceptor binding affinity and functional potency assaysHepatocyte and adipocyte lipid-handling models in vitroPeptide structure–activity relationship studiesAnalytical method development and reference-standard characterization

Clinical Research Applications

Metabolic regulation

Clinical research is exploring the compound's role in improving glucose homeostasis and insulin sensitivity.

Weight management

The compound is under investigation for its potential impact on body weight reduction in various patient populations.

Hepatic health

Clinical research is exploring the effects of triple agonism on liver fat reduction and metabolic dysfunction-associated steatotic liver disease.

Pancreatic function

The compound is under investigation for its influence on beta-cell function and markers of metabolic stress.

Cardiovascular markers

Clinical research is exploring the potential for improved lipid profiles and endothelial function associated with metabolic regulation.

The applications above describe areas of ongoing clinical investigation reported in the research literature. They are not indications of approved use, efficacy, or safety, and do not constitute medical or therapeutic claims.

Laboratory Research Protocol

Reconstitution

Reconstitute lyophilized powder in sterile-filtered, deionized water or an appropriate physiological buffer (e.g., PBS) to a concentration suitable for the specific assay, typically 1-5 mg/mL, ensuring gentle agitation until fully dissolved.

Storage

Store lyophilized powder at -20°C or -80°C for long-term stability. Once reconstituted, store in aliquots at -20°C and avoid repeated freeze-thaw cycles.

In-vitro reference range

Typical in-vitro assay concentrations for receptor binding and functional signaling studies range from picomolar to micromolar levels depending on the specific cell line and receptor expression density.

Handling notes

This compound is for in-vitro laboratory research only. Ensure all handling is performed in a controlled environment using standard aseptic techniques for peptide research.

Concentration ranges reflect values reported in published in-vitro assays and are provided as a literature reference only — not a dosing regimen for use in any organism.

Selected References

  • 01Triple-Hormone-Receptor Agonist Retatrutide for Obesity — New England Journal of Medicine
  • 02Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide — Cell Discovery
  • 03Triple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease: a randomized phase 2a trial — Nature Medicine
  • 04Retatrutide: a triple incretin receptor agonist for obesity management — Expert Opinion on Investigational Drugs

Compliance Statement

This product is supplied strictly for IN-VITRO LABORATORY RESEARCH ONLY. It is not a drug, supplement, food, or cosmetic, and is not intended for human or veterinary consumption, diagnosis, or treatment.